Wednesday, September 26, 2007

The heart v.s. the brain

One question I want to ask Gyorgy Buzsaki:
When we look at the wiring mechanism of neurons, is the heart comparable to the brain in some way?

Both in the heart and the brain, there're electrical events going on, there's resting potential and depolarization, there're similarly functioning ion channels. Oh, gap junctions, that's special in the heart. One difference is that, the target of the electrical signals are actually contented inside the heart, i.e., the whole events from stimulation to response, happens in the same organ. In contrast, it's more likely that the brain gives signal, and the outside receptors response.

But when we consider the electrical wiring of the brain, is it possible to use the heart as a simple model? You know, many ion channelists favor to choose the heart as the target organ for research, which contain simliarly functioning ion channels, but much easier for them to unravel the mechanisms underlying.

Or, given the gap junction thing, no way?

Well, I need to think more before I went up to ask him.

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